Registry-Based Pragmatic Trials in Heart Failure: Current Experience and Future Directions

Registry-Based Pragmatic Trials in Heart Failure: Current Experience and Future Directions

PURPOSE OF REVIEW Randomized controlled trials (RCTs) in heart failure (HF) are becoming increasingly complex and expensive to conduct and if positive deliver expensive therapy tested only in selected populations. RECENT FINDINGS Electronic health records and clinical cardiovascular quality registries are providing opportunities for pragmatic and registry-based prospective randomized clinical...

Swing-beds: current experience and future directions.

Beta-blockers in heart failure. Future directions.

The rationale for beta-blockade in heart failure is now well established. Heart failure mortality, which is predicted by neurohormonal activation, remains high despite modern treatment including ACE inhibition, and additional neurohormonal blockade has further therapeutic potential. Previous clinical trial experience in heart failure, most of which has been in patients with idiopathic cardiomyo...

The Minnesota Twin Registry: current status and future directions.

The Minnesota Twin Registry is a birth-record-based twin registry. Begun in 1983, it includes data for 4307 surviving intact pairs born in Minnesota between 1936 and 1955. In addition, the Registry includes 901 twin pairs born in Minnesota from 1904 to 1934, as well as 391 male pairs born in Minnesota from 1961 to 1964. The research focus is primarily on human individual differences assessed by...

AT1-receptor blockers in hypertension and heart failure: clinical experience and future directions.

In various manifestations of cardiovascular disease, blockade of the renin–angiotensin system by angiotensin converting enzyme (ACE) inhibitors has been shown to prevent or delay disease progression effectively and improve prognosis in terms of mortality and morbidity. Angiotensin type 1-receptor (AT1-receptor) blockers, on the other hand, are used for more specific and efficacious blockade of ...